Redundant roles for sox7 and sox18 in arteriovenous specification in zebrafish.
Identifieur interne : 006957 ( Main/Exploration ); précédent : 006956; suivant : 006958Redundant roles for sox7 and sox18 in arteriovenous specification in zebrafish.
Auteurs : Robert Herpers [Pays-Bas] ; Esther Van De Kamp ; Henricus J. Duckers ; Stefan Schulte-MerkerSource :
- Circulation research [ 1524-4571 ] ; 2008.
Descripteurs français
- KwdFr :
- Animaux, Aorte (croissance et développement), Artères (croissance et développement), Artères (embryologie), Artères (malformations), Danio zébré, Facteurs de transcription (analyse), Facteurs de transcription (physiologie), Facteurs de transcription SOX-F, Induction embryonnaire, Protéines HMG (analyse), Protéines HMG (physiologie), Protéines de liaison à l'ADN (analyse), Protéines de liaison à l'ADN (physiologie), Protéines de poisson-zèbre (physiologie), Vaisseaux sanguins (croissance et développement), Vaisseaux sanguins (embryologie), Vaisseaux sanguins (malformations), Veines (croissance et développement), Veines (embryologie), Veines (malformations).
- MESH :
- analyse : Facteurs de transcription, Protéines HMG, Protéines de liaison à l'ADN.
- croissance et développement : Aorte, Artères, Vaisseaux sanguins, Veines.
- embryologie : Artères, Vaisseaux sanguins, Veines.
- malformations : Artères, Vaisseaux sanguins, Veines.
- physiologie : Facteurs de transcription, Protéines HMG, Protéines de liaison à l'ADN, Protéines de poisson-zèbre.
- Animaux, Danio zébré, Facteurs de transcription SOX-F, Induction embryonnaire.
English descriptors
- KwdEn :
- Animals, Aorta (growth & development), Arteries (abnormalities), Arteries (embryology), Arteries (growth & development), Blood Vessels (abnormalities), Blood Vessels (embryology), Blood Vessels (growth & development), DNA-Binding Proteins (analysis), DNA-Binding Proteins (physiology), Embryonic Induction, High Mobility Group Proteins (analysis), High Mobility Group Proteins (physiology), SOXF Transcription Factors, Transcription Factors (analysis), Transcription Factors (physiology), Veins (abnormalities), Veins (embryology), Veins (growth & development), Zebrafish, Zebrafish Proteins (physiology).
- MESH :
- chemical , analysis : DNA-Binding Proteins, High Mobility Group Proteins, Transcription Factors.
- abnormalities : Arteries, Blood Vessels, Veins.
- embryology : Arteries, Blood Vessels, Veins.
- growth & development : Aorta, Arteries, Blood Vessels, Veins.
- chemical , physiology : DNA-Binding Proteins, High Mobility Group Proteins, Transcription Factors, Zebrafish Proteins.
- Animals, Embryonic Induction, SOXF Transcription Factors, Zebrafish.
Abstract
The specification of arteries and veins is an essential process in establishing and maintaining a functional blood vessel system. Incorrect arteriovenous specification disrupts embryonic development but has also been diagnosed in human syndromes such as hypotrichosis-lymphedema-telangiectasia, characterized by defects in blood and lymphatic vessels and associated with mutations in SOX18. Here we characterize the role of sox7 and sox18 during zebrafish vasculogenesis. Sox7 and sox18 are specifically expressed in the developing vasculature, and simultaneous loss of their function results in a severe loss of the arterial identity of the presumptive aorta which instead expresses venous markers, followed by dramatic arteriovenous shunt formations. Our study identifies members of the Sox family as key factors in specifying arteriovenous identity and will help to better understand hypotrichosis-lymphedema-telangiectasia and other diseases.
DOI: 10.1161/CIRCRESAHA.107.166066
PubMed: 18032732
Affiliations:
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Le document en format XML
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Duckers</name></author><author><name sortKey="Schulte Merker, Stefan" sort="Schulte Merker, Stefan" uniqKey="Schulte Merker S" first="Stefan" last="Schulte-Merker">Stefan Schulte-Merker</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18032732</idno><idno type="pmid">18032732</idno><idno type="doi">10.1161/CIRCRESAHA.107.166066</idno><idno type="wicri:Area/PubMed/Corpus">003468</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003468</idno><idno type="wicri:Area/PubMed/Curation">003468</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003468</idno><idno type="wicri:Area/PubMed/Checkpoint">003468</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003468</idno><idno type="wicri:Area/Ncbi/Merge">002A24</idno><idno type="wicri:Area/Ncbi/Curation">002A24</idno><idno type="wicri:Area/Ncbi/Checkpoint">002A24</idno><idno type="wicri:Area/Main/Merge">006A50</idno><idno type="wicri:Area/Main/Curation">006957</idno><idno type="wicri:Area/Main/Exploration">006957</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Redundant roles for sox7 and sox18 in arteriovenous specification in zebrafish.</title><author><name sortKey="Herpers, Robert" sort="Herpers, Robert" uniqKey="Herpers R" first="Robert" last="Herpers">Robert Herpers</name><affiliation wicri:level="1"><nlm:affiliation>Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht</wicri:regionArea><wicri:noRegion>3584 CT Utrecht</wicri:noRegion></affiliation></author><author><name sortKey="Van De Kamp, Esther" sort="Van De Kamp, Esther" uniqKey="Van De Kamp E" first="Esther" last="Van De Kamp">Esther Van De Kamp</name></author><author><name sortKey="Duckers, Henricus J" sort="Duckers, Henricus J" uniqKey="Duckers H" first="Henricus J" last="Duckers">Henricus J. Duckers</name></author><author><name sortKey="Schulte Merker, Stefan" sort="Schulte Merker, Stefan" uniqKey="Schulte Merker S" first="Stefan" last="Schulte-Merker">Stefan Schulte-Merker</name></author></analytic><series><title level="j">Circulation research</title><idno type="eISSN">1524-4571</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Aorta (growth & development)</term><term>Arteries (abnormalities)</term><term>Arteries (embryology)</term><term>Arteries (growth & development)</term><term>Blood Vessels (abnormalities)</term><term>Blood Vessels (embryology)</term><term>Blood Vessels (growth & development)</term><term>DNA-Binding Proteins (analysis)</term><term>DNA-Binding Proteins (physiology)</term><term>Embryonic Induction</term><term>High Mobility Group Proteins (analysis)</term><term>High Mobility Group Proteins (physiology)</term><term>SOXF Transcription Factors</term><term>Transcription Factors (analysis)</term><term>Transcription Factors (physiology)</term><term>Veins (abnormalities)</term><term>Veins (embryology)</term><term>Veins (growth & development)</term><term>Zebrafish</term><term>Zebrafish Proteins (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Aorte (croissance et développement)</term><term>Artères (croissance et développement)</term><term>Artères (embryologie)</term><term>Artères (malformations)</term><term>Danio zébré</term><term>Facteurs de transcription (analyse)</term><term>Facteurs de transcription (physiologie)</term><term>Facteurs de transcription SOX-F</term><term>Induction embryonnaire</term><term>Protéines HMG (analyse)</term><term>Protéines HMG (physiologie)</term><term>Protéines de liaison à l'ADN (analyse)</term><term>Protéines de liaison à l'ADN (physiologie)</term><term>Protéines de poisson-zèbre (physiologie)</term><term>Vaisseaux sanguins (croissance et développement)</term><term>Vaisseaux sanguins (embryologie)</term><term>Vaisseaux sanguins (malformations)</term><term>Veines (croissance et développement)</term><term>Veines (embryologie)</term><term>Veines (malformations)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>DNA-Binding Proteins</term><term>High Mobility Group Proteins</term><term>Transcription Factors</term></keywords><keywords scheme="MESH" qualifier="abnormalities" xml:lang="en"><term>Arteries</term><term>Blood Vessels</term><term>Veins</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Facteurs de transcription</term><term>Protéines HMG</term><term>Protéines de liaison à l'ADN</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Aorte</term><term>Artères</term><term>Vaisseaux sanguins</term><term>Veines</term></keywords><keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Artères</term><term>Vaisseaux sanguins</term><term>Veines</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Arteries</term><term>Blood Vessels</term><term>Veins</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Aorta</term><term>Arteries</term><term>Blood Vessels</term><term>Veins</term></keywords><keywords scheme="MESH" qualifier="malformations" xml:lang="fr"><term>Artères</term><term>Vaisseaux sanguins</term><term>Veines</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Facteurs de transcription</term><term>Protéines HMG</term><term>Protéines de liaison à l'ADN</term><term>Protéines de poisson-zèbre</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>DNA-Binding Proteins</term><term>High Mobility Group Proteins</term><term>Transcription Factors</term><term>Zebrafish Proteins</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Embryonic Induction</term><term>SOXF Transcription Factors</term><term>Zebrafish</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Danio zébré</term><term>Facteurs de transcription SOX-F</term><term>Induction embryonnaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The specification of arteries and veins is an essential process in establishing and maintaining a functional blood vessel system. Incorrect arteriovenous specification disrupts embryonic development but has also been diagnosed in human syndromes such as hypotrichosis-lymphedema-telangiectasia, characterized by defects in blood and lymphatic vessels and associated with mutations in SOX18. Here we characterize the role of sox7 and sox18 during zebrafish vasculogenesis. Sox7 and sox18 are specifically expressed in the developing vasculature, and simultaneous loss of their function results in a severe loss of the arterial identity of the presumptive aorta which instead expresses venous markers, followed by dramatic arteriovenous shunt formations. Our study identifies members of the Sox family as key factors in specifying arteriovenous identity and will help to better understand hypotrichosis-lymphedema-telangiectasia and other diseases.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><noCountry><name sortKey="Duckers, Henricus J" sort="Duckers, Henricus J" uniqKey="Duckers H" first="Henricus J" last="Duckers">Henricus J. Duckers</name><name sortKey="Schulte Merker, Stefan" sort="Schulte Merker, Stefan" uniqKey="Schulte Merker S" first="Stefan" last="Schulte-Merker">Stefan Schulte-Merker</name><name sortKey="Van De Kamp, Esther" sort="Van De Kamp, Esther" uniqKey="Van De Kamp E" first="Esther" last="Van De Kamp">Esther Van De Kamp</name></noCountry><country name="Pays-Bas"><noRegion><name sortKey="Herpers, Robert" sort="Herpers, Robert" uniqKey="Herpers R" first="Robert" last="Herpers">Robert Herpers</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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